Beagle Body Builders: A rare genetic syndrome

by Jemma Cooper-Boot BSc RVN Dip. Ani. Phys MIAAT Musladin-Lueke Syndrome (MLS), commonly known as Chinese Beagle syndrome, is a hereditory recessive disorder found in Beagle dogs that manifests with extensive fibrosis of the skin and joints caused by gene defects affecting fibrillin-1, a major component of tissue microfibrils (Bader et al, 2010). Typically, affected beagles have shorter outer toes and walk very upright on their front feet resembling a ballerina stance on digits 3 and 4. In some cases, all four feet are affected. They have tighter skin with limited scruff and their bodies feel hard due to tight...

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